Pyrrolidine derivatives as cyclic amp-specific...

Details Pyrrolidine derivatives as cyclic amp-specific... Pyrrolidine derivatives as cyclic amp-specific...

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2395193

Novel pyrrolidine compounds having the structural formula (II) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

La présente invention concerne des composés de pyrrolidine représentés par la formule structurelle suivante (II). Ces composés constituent de puissants inhibiteurs sélectifs de la PDE4. L'invention concerne également les procédés de fabrication de ces composés. L'invention concerne enfin l'utilisation de ces composés pour le traitement d'affections inflammatoires et d'autres affections à niveaux élevés de cytokines, mais aussi pour le traitement de troubles du système nerveux central.

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