C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2720285
The present invention relates to a compounds of formula I wherein R1, R2, R3, R', Ar, o, n and m are as defined in the specification. It has been found that the present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
La présente invention concerne des composés de formule I dans laquelle R1, R2, R3, R', Ar, o, n et m sont tels que définis dans la description. Il a été découvert que les composés de la présente invention sont des antagonistes des récepteurs NK3 à potentiel élevé pour le traitement de la dépression, de la douleur, de la psychose, de la maladie de Parkinson, de la schizophrénie, de lanxiété et du trouble dhyperactivité avec déficit de lattention (THADA).
Jablonski Philippe
Kawasaki Kenichi
Knust Henner
Limberg Anja
Nettekoven Matthias
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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