Pyrrolidine modulators of chemokine receptor activity

Details Pyrrolidine modulators of chemokine receptor activity Pyrrolidine modulators of chemokine receptor activity

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01

Patent

CA 2366944

The present invention is directed to pyrrolidine compounds of formula (I) (wherein R1, R2, R3, R4, R5, R6 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

L'invention concerne des composés de pyrrolidine représentés dans la formule I: (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et n sont définis dans celle-ci) lesquels composés sont utilisés comme modulateurs de l'activité du récepteur des chimiokines. En particulier, lesdits composés sont utilisés comme modulateurs des récepteurs CCR-5 et/ou CCR-3 des chimiokines.

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