Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/407 (2006.01)

Patent

CA 2341991

A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

L'invention concerne un composé chimique de la formule (I) dans laquelle n représente 1, 2 ou 3; R1 et R2 sont indépendamment sélectionnés dans le groupe formé par hydrogène et alkyle; R3 représente un alkyle; R4 à R7 sont indépendamment sélectionnés dans le groupe formé par hydrogène, halogène, hydroxy, alkyle, aryle, alcoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyle, alkylsulfonyle, arylsulfoxyle, arylsulfonyle, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldéhyde, alkylcarbonyle, arylcarbonyle, aminocarbonyle, monoalkylaminocarbonyle, dialkylaminocarbonyle, alcoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino et dialkylaminocarbonylamino; ou R5 et R6 pris ensemble forment un noyau carbocyclique ou hétérocyclique. L'invention concerne également des sels et des promédicaments de ce composé acceptables du point de vue pharmaceutique, ainsi que leur utilisation pour une thérapie, notamment pour le traitement de troubles du système nerveux central; de lésions du système nerveux central; de troubles cardiovasculaires; de troubles gastro-intestinaux; du diabète insipide et de l'apnée du sommeil, et en particulier pour le traitement de l'obésité.

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