Pyrrolopyridine derivatives and use of same as ppar receptor...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2620662

The invention relates to pyrrolopyridine derivative compounds having general formula (I) as defined in the claims and to the pharmaceutically-acceptable addition salts thereof. The invention also relates to the method of preparing the aforementioned compounds, to pharmaceutical compositions containing same and to the use thereof as a pharmacologically-active substance, for example in the treatment of hypertriglyceridaemias, hyperlipidemias, hypercholesterolemias, diabetes, endothelial dysfunction, cardiovascular and inflammatory diseases and neurodegeneration.

L'invention concerne des composés dérivés de pyrrolopyridine de formule générale (I): telle que définie dans les revendications, et leurs sels d'addition pharmaceutiquement acceptable. Elle concerne également leur procédé de préparation, les compositions pharmaceutiques les contenant, et leur utilisation en tant que substance pharmacologiquement active, notamment dans le traitement des hypertriglycéridémies, des hyperlipidémies, des hypercholestérolémies, du diabète, de la dysfonction endothéliale, des maladies cardiovasculaires, inflammatoires et des neurodégénérescences.

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