Pyrrolopyrimidine compounds as cdk inhibitors

Details Pyrrolopyrimidine compounds as cdk inhibitors Pyrrolopyrimidine compounds as cdk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2734802

The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

L'invention concerne des composés concernant des traitements et des thérapies contre des pathologies associées à des protéines kinases. L'invention concerne également des composés utilisés dans le traitement, la prévention ou l'amélioration d'un ou plusieurs symptômes du cancer, des rejets de greffes, et des maladies autoimmunes. De plus, l'invention concerne des méthodes pour moduler l'activité des protéines kinases, telles que la CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 et CDK9, à l'aide des composés de l'invention.

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