C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2560699
Methods for detecting populations of newly synthesized and newly initiated RNAs in a cell-free system are described. Suitable templates for the populations of newly synthesized and newly initiated RNAs are viral replicon RNAs, particularly HCV viral replicon RNA. The newly synthesized and newly initiated RNAs may be formed in the presence of a labeled nucleotide analog suitable for detection and/or quantitation of the RNAs. The assay may be employed to identify small molecule inhibitors of RNA synthesis of positive strand RNA viruses such as Hepatitis C Virus.
L'invention porte sur des procédés de détection de populations d'ARN récemment synthétisés et amorcés dans un système exempt de cellules. Les gabarits appropriés des populations des ARN récemment synthétisés et amorcés sont des ARN de réplicon viraux, notamment l'ARN de réplicon viral du virus de l'hépatite C. Les ARN récemment synthétisés et amorcés peuvent se répliquer en présence d'un analogue de nucléotide marqué approprié à la détection et/ou la quantitatif des ARN. Le test peut être utilisé pour identifier des inhibiteurs de petites molécules de la synthèse de l'ARN des virus d'ARN à brin positif tels que le virus de l'hépatite C.
Huang Mingjun
Sun Yongnian
Yang Wengang
Achillion Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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