Quaternized pei silica solid supports for chromatography

B - Operations – Transporting – 01 – J

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B01J 41/14 (2006.01) B01J 20/32 (2006.01) B01J 41/20 (2006.01)

Patent

CA 2022741

Quaternized non-crosslinked polyethyleneimine silica based solid supports are useful strong anion exchangers for column chromatography separation and purification of proteins and have high binding capacity at high pH, the ability to bind basic proteins having high pH isoelectric points and are rapidly equilibrated and are essentially non-titratable.

Supports solides à base de polyéthylèneimine-silice quaternisée non réticulée, puissants échangeurs d'anions, pour séparation et purification de protéines sur colonnes chromatographiques; ils possèdent une forte capacité de liaison à pH élevé et la capacité de fixer des protéines basiques à pH isoélectrique élevé; enfin, ils atteignent rapidement l'équilibre et sont pratiquement non titrables.

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