Quinazoline derivatives and a process for their production

Details Quinazoline derivatives and a process for their production Quinazoline derivatives and a process for their production

C - Chemistry, Metallurgy

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C07D 239/95 (2006.01) C07D 239/96 (2006.01) C07D 285/24 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 1289139

ABSTRACT OF THE DISCLOSURE Quinazoline derivatives of the formula: Image in which R1 and R2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R3 is aryl or ar(lower)alkyl, both of which may have one or more suitable sub- stituent(s), or heterocyclic(lower)alkyl, R4 is carboxy or protected carboxy, A is oxygen or sulfur atom, Y is carbonyl, thiocarbonyl or sulfonyl and Z is lower alkylene, and pharmaceutically acceptable salts thereof, exhibit an aldose reductase-inhibitory activity and may be used in the therapeutic treatment of diabetic complications, for example corneal wound healing defects

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