C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2527017
The invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R11, N, Z, A, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (I) and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).
L'invention concerne des composés de le formule (1) et des sels pharmaceutiquement acceptables, des promédicaments et des solvates desdits composés. Dans cette formule, R?1¿, R?3¿, R?4¿, R?11¿, N, Z, A, m et p ont la définition mentionnée dans la description. L'invention concerne également des procédés de traitement du développement anormal de cellules chez des mammifères, par administration desdits composés de la formule (1) et des compositions pharmaceutiques pour traiter de tels troubles, qui contiennent les composés de la formule (1). L'invention concerne en outre des procédés de préparation des composés de la formule (1).
Bhattacharya Samit Kumar
Chen Jinshan
Connell Richard Damian
Kath John Charles
Kauffman Goss Stryker
Pfizer Products Inc.
Smart & Biggar
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