Quinazolinone derivatives and their use as b-raf inhibitors

Details Quinazolinone derivatives and their use as b-raf inhibitors Quinazolinone derivatives and their use as b-raf inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/90 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2577275

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

La présente invention a pour objet des composés chimiques de formule (I) : ou des sels de qualité pharmaceutique de ces composés. Lesdits composés présentent une activité inhibitrice vis-à-vis du gène B Raf, et sont de ce fait utilisés pour leurs propriétés anticancéreuses, plus spécifiquement pour le traitement d~organismes humains ou animaux. La présente invention décrit également des procédés de fabrication desdits composés chimiques, des préparations pharmaceutiques les contenant, ainsi que leur utilisation dans la fabrication de médicaments ayant un effet anticancéreux chez un animal à sang chaud tel que l~homme.

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