Quinoline derivatives and their use as 5-ht6 ligands

Details Quinoline derivatives and their use as 5-ht6 ligands Quinoline derivatives and their use as 5-ht6 ligands

C - Chemistry, Metallurgy

07

D

C07D 215/40 (2006.01) A61K 31/47 (2006.01) A61P 25/00 (2006.01) C07D 215/00 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2479786

The present invention relates to quinoline compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent hydrogen or C1-6 alkyl or R1 is linked to R2 to form a group (CH2)2, (CH2)3 or (CH2)4; R3, R4 and R5 independently represent hydrogen, halogen, cyano, -CF3, -CF3O, C1-6 alkyl, C1-6 alkoxy, C1-6 alkanoyl or a group - CONR6R7; m represents an integer from 1 to 4, such that when m is an integer greater than 1, two R2 groups may instead be linked to form a group CH2, (CH2)2 or (CH2)3; n represents an integer from 1 to 3; p represents 1 or 2; A represents a group -Ar1 or -Ar2Ar3; Ar1, Ar2 and Ar3 independently represent and aryl group or a heteroaryl group, both of which may be optionally substituted by one or more substituents having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.

L'invention concerne des composés quinoline possédant une activité pharmacologique, des procédés de préparation de ces composés, des compositions les contenant ainsi que leurs utilisations dans le traitement du système nerveux central et d'autres troubles.

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