Quinoline derivatives as immunomodulators

Details Quinoline derivatives as immunomodulators Quinoline derivatives as immunomodulators

C - Chemistry, Metallurgy

07

D

C07D 215/56 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 405/02 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/06 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2214521

Quinoline derivatives of formula (I), wherein R1 is hydrogen, halogen, lower (see fig.I) alkyl, etc., R2 is hydroxy or protected hydroxy, R3 is lower alkyl, etc., (a) is a (see fig.II) (a) (see fig.III) (i) group of formula (i) (in which R4 is lower alkyl, lower alkenyl, lower alkoxy(lower)alkyl, cyclo(lower)alkyl or lower alkoxy(lower)alkoxy(lower)-alkyl, and R5 is aryl which may have suitable substituent(s) or heterocyclic group), etc., R7 is hydrogen or halogen, R8 is hydrogen or lower alkyl, etc., and Z is O or S, and a pharmaceutically acceptable salt thereof which are useful as a medicament.

Dérivés de la quinoléine de formule (I), dans laquelle R1 est un atome d'hydrogène, un atome d'halogène, un groupe alkyle inférieur (voir fig.I), etc., R2 est un groupe hydroxy ou un groupe hydroxy protégé, R3 est un groupe alkyle inférieur, etc., (a) est (voir fig.II) (a) (voir fig.III) (i) un groupe de formule (i) (dans lequel R4 est un groupe alkyle inférieur, un groupe alcényle inférieur, un groupe alkoxyalkyle(inférieur), un groupe cycloalkyle(inférieur) ou un groupe alkoxyalkoxy(inférieur)alkyle(inférieur), et R5 est un groupe aryle pouvant porter un(des) substituant(s) approprié(s), ou un groupe hétérocyclique), etc., R7 est un atome d'hydrogène ou un atome d'halogène, R8 est un atome d'hydrogène ou un groupe alkyle inférieure, etc., et Z est un O ou un S, et un sel acceptable du point de vue pharmaceutique qui est utile comme médicament.

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