C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2616547
The present invention relates to substituted quinoline derivatives of Formula (I); wherein hal, n, A, formula (a) , R1, R2, R3, R4, R5 and R6 are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.
La présente invention concerne des dérivés de quinoline substitués qui répondent à la formule (I); où hal, n, A, la formule (a), R1, R2, R3, R4, R5 et R6 sont tels que définis dans le présent document, des compositions pharmaceutiques comprenant ceux-ci et leur utilisation dans le traitement des maladies induites par les récepteurs de neurokinine-2 et/ou de neurokinine-3 (NK-3). Ces composés peuvent être utilisés dans le cadre de procédés thérapeutiques visant à éliminer et à traiter de telles pathologies.
Crawforth James Michael
Williams Brian John
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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