A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/211, 260/277
A61K 31/47 (2006.01) A61K 31/535 (2006.01) C07D 215/46 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1266650
QUINOLINE DERIVATIVES A b s t r a c t The invention relates to new quinoline derivatives of the general Formula I (I) Image (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general Formula IV, Image (IV) wherein Z stands for -O-, -S-, -NH- or -N(lower alkyl)-; the dotted lines represent optional bonds; and m is 0 or 1; or R1 and R2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered hetero- cyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiatior and may be used in radiation therapy.
510779
Berenyi Edit Nee Poldermann
Hartai Eva Nee Zsorzs
Kovacs Agnes Nee Palotai
Ladanyi Laszlo
Pallos Laszlo
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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