Quinoline or isoquinoline substituted p2x7 antagonists

Details Quinoline or isoquinoline substituted p2x7 antagonists Quinoline or isoquinoline substituted p2x7 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4427 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2722035

The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I)

La présente invention porte sur de nouveaux composés de formule (I) ayant des propriétés antagonistes de P2X7, sur des compositions pharmaceutiques comprenant ces composés, sur des procédés chimiques pour préparer ces composés et sur leur utilisation dans le traitement ou la prophylaxie de maladies associées à une activité des récepteurs de P2X7 chez les animaux, en particulier les êtres humains. (I)

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