Quinolinone derivatives as inhibitors of c-fms kinase

Details Quinolinone derivatives as inhibitors of c-fms kinase Quinolinone derivatives as inhibitors of c-fms kinase

A - Human Necessities

61

K

A61K 31/4704 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 215/22 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2533626

The invention is directed to compounds of Formulae I and II, wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

La présente invention a trait à des composés de formules I et II, dans lesquelles : R?1¿, R?2¿, R?3¿, R?5¿, R?6¿, Y?1¿, Y?2¿, Y?3¿, Y?4¿ et X sont tels que définis dans la description, ainsi que leurs solvates, hydrates, tautomères ou leurs sels pharmaceutiquement acceptables, présentant un activité d'inhibition des tyrosine kinases, notamment de la c-fms kinase.

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