Quinolinone derivatives as tyrosine kinase inhibitors

Details Quinolinone derivatives as tyrosine kinase inhibitors Quinolinone derivatives as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2421120

Organic compounds having the formulas I and II are provided [SEE FORMULA I] [SEE FORMULA II] where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

L'invention concerne des composés organiques ayant les formules (I et II) dans lesquelles les variables ont les valeurs décrites dans la description. L'invention concerne également des formulations pharmaceutiques contenant les composés organiques ou leur sel pharmaceutiquement acceptable ainsi qu'un excipient pharmaceutiquement acceptable pouvant être préparées par mélange des composés organiques ou de sels pharmaceutiquement acceptables des composés organiques avec un excipient et de l'eau. L'invention concerne également une méthode de traitement d'un patient consistant à administrer une formulation pharmaceutique selon l'invention à un patient la nécessitant.

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