C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2475637
Selected compounds of formula (I) wherein (a) is (b) or (c) wherein A is O, S or NH; wherein D is CR1 or N; wherein E is CR2 or N; wherein F is CR3 or N; wherein F is CR4 or N; wherein J is selected from NR6, S, O, and CR1 wherein K is selected from NR6 , S, O, and CR2; wherein L is selected from NR6, S, O, and CR3 are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Selon l'invention, les composés sélectionnés sont efficaces pour traiter des maladies telles que la prolifération cellulaire ou celles à médiation par apoptose. L'invention comprend de nouveaux composés, analogues, promédicaments et leurs dérivés pharmaceutiquement acceptables, des compositions pharmaceutiques et des procédés de prévention et de traitement de maladies et d'autres états ou pathologies liés à l'ictus, au cancer ou similaire. L'invention concerne aussi des procédés pour fabriquer ces composés ainsi que des intermédiaires utiles dans ces processus.
Kaller Matthew
Liu Hu
Nguyen Thomas
Norman Mark
Rzasa Robert
Amgen Inc.
Osler Hoskin & Harcourt Llp
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