C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 455/02 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2711487
The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
La présente invention concerne des composés de formule (I) qui sont des modulateurs allostériques positifs du récepteur M1 et qui sont utiles pour traiter des maladies dans lesquelles est impliqué le récepteur M1, telles que la maladie d'Alzheimer, la schizophrénie, la douleur ou des troubles du sommeil. L'invention concerne également des compositions pharmaceutiques comprenant les composés et l'utilisation des composés et des compositions dans le traitement de maladies médiées par le récepteur M1.
Chang Ronald K.
Kuduk Scott D.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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