Quinolone derivatives

Details Quinolone derivatives Quinolone derivatives

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 401/04 (2006.01) C07D 215/56 (2006.01) C07D 257/04 (2006.01) C07D 265/26 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1244420

Abstract A process is disclosed for the preparation of quinolones of the formula I Image wherein the dotted line between positions 2 and 3 of the quinolone ring represents an optional bond, R is hydrogen, 1-methyl or 2-lower alkyl; R1 is lower alkyl; R2 is hydrogen, halo, lower alkyl, lower alkoxy, trifluoromethyl, cyano, difluoromethoxy, lower alkylsulphinyl, phenylsulphinyl or the group -NR4R5 or an N-oxide thereof wherein R4 and R5, which may be the same or different, are lower alkyl or, together with the nitrogen atom to which they are attached, form a pyrrolidino, piperidino or morpholino radical; and R3 is hydrogen, fluoro, lower alkyl or lower alkoxy provided that, when R3 is lower alkoxy, R2 is other than lower alkoxy. The compounds are antihypertensive agents and are also useful for treating ischaemic heart disease and/or heart failure.

461302

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