Quinolones useful as inducible nitric oxide synthase inhibitors

Details Quinolones useful as inducible nitric oxide synthase inhibitors Quinolones useful as inducible nitric oxide synthase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/395 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01) A61P 29/00 (2006.01) C07D 215/227 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2643011

The present invention relates to novel quinolones of Formula (I) that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.

La présente invention concerne des quinolones innovantes de formule (I) qui inhibent la NOS-synthase inductible ainsi que des procédés de synthèse et d'utilisation des composés, y compris des procédés permettant d'inhiber ou de moduler la synthèse de l'oxyde nitrique et/ou d'abaisser le taux d'oxyde nitrique chez un patient en administrant les composés pour le traitement d'une maladie.

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