C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/90 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) C07C 215/16 (2006.01) C07C 215/50 (2006.01) C07C 215/76 (2006.01) C07C 217/58 (2006.01) C07C 217/82 (2006.01) C07C 217/84 (2006.01) C07C 217/86 (2006.01) C07C 217/88 (2006.01) C07C 225/22 (2006.01) C07C 229/60 (2006.01) C07C 233/69 (2006.01) C07C 235/38 (2006.01) C07C 237/30 (2006.01) C07C 237/38 (2006.01) C07C 239/20 (2006.01) C07C 255/55 (2006.01) C07C 255/58 (2006.01) C07C 275/34 (2006.01) C07C 311/04 (2006.01) C07C 311/21 (2006.01) C07C 31
Patent
CA 2345103
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
L'invention concerne des composés d'aryl et d'hétéroaryl-amino-(n+1)-alcanol 1-halogénés R-chiraux, utiles comme inhibiteurs de l'activité de la protéine de transfert de l'ester de cholestéryle (CETP, protéine de transfert des lipides plasmatiques 1), ainsi que des composés, des compositions et des méthodes permettant de traiter l'athérosclérose et d'autres maladies des artères coronaires. L'invention concerne également de nouveaux procédés stéréosélectifs à haut rendement, qui permettent de préparer lesdits composés d'alcanols substitués chiraux à partir d'intermédiaires chiraux et achiraux.
Durley Richard C.
Fobian Yvette M.
Grapperhaus Margaret L.
Hamme Ashton T.
Hickory Brian S.
Monsanto Company
Pharmacia Corporation
Smart & Biggar
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