R-hydroxynitrile lyases having improved substrate acceptance...

Details R-hydroxynitrile lyases having improved substrate acceptance... R-hydroxynitrile lyases having improved substrate acceptance...

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01)

Patent

CA 2519633

The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.

R-hydroxynitrillyases de la famille des Rosacées présentant une meilleure compatibilité avec le substrat et une meilleure stabilité, dans le centre actif desquelles (a) un reste alanine est substitué par glycine, valine, leucine, isoleucine ou phénylalanine ou (b) un reste phénylalanine est substitué par alanine, glycine, valine, leucine ou isoleucine ou (c) un reste leucine est substitué par alanine, glycine, valine, isoleucine ou phénylalanine ou (d) un reste isoleucine est substitué par alanine, glycine, valine, leucine ou phénylalanine, et utilisation desdites substances pour produire des <I>R</I>- ou <I>S</I>-cyanhydrines exemptes d'énantiomères.

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