Racemic and optically pure metabolites of sibutramine, their...

Details Racemic and optically pure metabolites of sibutramine, their... Racemic and optically pure metabolites of sibutramine, their...

C - Chemistry, Metallurgy

07

C

C07C 211/29 (2006.01) A61K 31/137 (2006.01) A61K 31/205 (2006.01) A61P 25/02 (2006.01) C07C 45/44 (2006.01) C07C 47/457 (2006.01) C07C 209/88 (2006.01) C07C 251/18 (2006.01)

Patent

CA 2396950

Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic or optically pure sibutramine metabolite, and optionally an additional pharmacologically active compound.

L'invention porte sur des procédés d'obtention et d'utilisation de métabolites racémiques et optiquement purs de la sibutramine, sur leurs sels, solvates, et clathrates pharmacocompatibles, ainsi que sur des préparations pharmaceutiques et formes posologiques comportant des inhibiteurs du recaptage de la dopamine tels qu'un métabolite racémique et optiquement pur de la sibutramine, et facultativement un composé pharmacologiquement actif additionnel.

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