Radiolabeled glucans

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/08 (2006.01) A61K 51/04 (2006.01) A61K 51/06 (2006.01)

Patent

CA 2167807

This invention relates to radiodiagnostic agents and reagents for preparing such agents, and also methods for producing radiolabelled radiodiagnostic agents. Specifically, the invention relates to technetium-99m (99mTc) labelled agents, methods and kits for making the agents, and methods for wing the agents to image pathological sites, including sites of infection, inflammation, cancer and atherosclerosis in a mammalian body. Specifically, the agents and reagents are derivatives of oligosaccharides, more specifically .beta.-glucans.

L'invention porte sur des agents de radiodiagnostic et des réactifs utilisés dans leur préparation et également sur des méthodes d'obtention desdits agents. L'invention se rapporte spécifiquement à des agents marqués au technétium-99m (99mTc) sur des méthodes et trousses de préparation desdits agents et leur méthode d'utilisation permettant de visualiser des sites pathologiques y compris des sites d'infection, d'inflammation, de cancer et d'athérosclérose chez les mammifères. Les agents et réactifs en question sont specifiquement des dérivés d'oligosaccharides et plus spécifiquement encore de 'beta'-glycannes.

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