Random peptides that bind to gastro-intestinal tract (git)...

Details Random peptides that bind to gastro-intestinal tract (git)... Random peptides that bind to gastro-intestinal tract (git)...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/51 (2006.01) A61K 38/02 (2006.01) A61K 38/09 (2006.01) A61K 38/28 (2006.01) C07K 1/04 (2006.01) C07K 5/00 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2290756

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro- intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastro-intestinal tract, thus facilitating its absorption into the systemic system.

L'invention concerne des protéines (par exemple des peptides) capable de faciliter le transport d'un agent actif à travers les tissus gastro-intestinaux d'un humain ou d'un animal. L'invention concerne également des dérivés (par exemple des fragments) et des analogues de ces protéines, ainsi que des séquences nucléotidiques codant ces protéines et ces dérivés. Les protéines de cette invention sont utiles pour faciliter le transport d'agents actifs depuis le côté lumière desdits tissus gastro-intestinaux, jusque dans l'appareil cardiovasculaire systémique, et/ou pour diriger des agents actifs vers ces tissus. Ainsi, par exemple, grâce à la liaison (par covalence ou non) d'une protéine de cette invention à un médicament administré par voie orale, ce médicament peut être dirigé vers des sites récepteurs spécifiques ou des voies de transport connues pour fonctionner dans le tractus gastrointestinal humain, facilitant ainsi son absorption dans le système systémique.

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