Rapamycin arylcarbonyl and alkoxycarbonyl as...

Details Rapamycin arylcarbonyl and alkoxycarbonyl as... Rapamycin arylcarbonyl and alkoxycarbonyl as...

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2148247

2148247 9410176 PCTABS00032 N-arylcarbonyl and N-alkylcarbonyl carbamates of rapamycin of formula (I), wherein R1 is (a) and R2 is H or (b) or R1 and R2 are both (a) and where A is lower alkoxy or aryl or heteroaryl, R3 is H or methyl and R4 is C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl possess immunosuppressive and/or antifungal and/or antitumor and/or antiinflammatory activity in vitro) and/or inhibit thymocyte proliferation in vivo. These compounds are thus expected to be useful in the treatment of transplantation rejection, autoimmune diseases, fungal infections, cancer, and diseases of inflammation.

Affiliated with

Also associated with

Rating

Rapamycin arylcarbonyl and alkoxycarbonyl as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rapamycin arylcarbonyl and alkoxycarbonyl as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapamycin arylcarbonyl and alkoxycarbonyl as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1948036