Reagents and methods for the formation of disulfide bonds...

Details Reagents and methods for the formation of disulfide bonds... Reagents and methods for the formation of disulfide bonds...

C - Chemistry, Metallurgy

07

H

C07H 5/10 (2006.01) C12N 9/44 (2006.01) C12N 9/56 (2006.01)

Patent

CA 2529341

Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The methods utilise thiosulfonate or selenenylsulfide compounds as reagents or intermediates. Some proteins and peptides comprising selenenylsulfide groups also form part of the invention.

La présente invention concerne des procédés et des réactifs pour former des liaisons disulfure, notamment dans des protéines, des peptides et des acides aminés. Ces procédés et réactifs sont notamment utilisés pour la glycosylation contrôlée de protéines, de peptides et d'acides aminés. Les procédés mettent en oeuvre des composés de thiosulfate et de sélénénylsulfure en tant que réactifs ou produits intermédiaires. La présente invention concerne également certaines protéines et certains peptides qui comprennent des groupes sélénénylsulfure.

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