Reagents and methods useful for detecting diseases of the...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2367125

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

On décrit un ensemble de séquences d'ADNc contiguës et partiellement superposées et des polypeptides codés par ces dernières, qui ont pour nom PCIGF et dont la transcription provient de tissus de la prostate. Ces séquences sont utiles pour détecter, diagnostiquer, classifier par stades, surveiller, pronostiquer, visualiser par imagerie in vivo, prévenir ou traiter, ou encore pour déterminer la prédisposition d'un individu à développer des maladies ou des troubles de la prostate, tels que le cancer de la prostate. On décrit également des anticorps qui se lient de manière spécifique à une protéine ou un polypeptide codé par PCIGF et des agonistes ou des inhibiteurs qui s'opposent à l'action du polypeptide PCIGF à spécificité tissulaire, avec des molécules qui sont utiles pour le traitement thérapeutique des maladies, des tumeurs ou des métastases de la prostate.

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