C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2316017
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS135 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS135-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS135 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention concerne une série de séquences d'ADNc contiguës et se chevauchant partiellement. L'invention concerne également les polypeptides que codent ces séquences, appelés BS135 et obtenus par transcription depuis le tissu du sein. Lesdites séquences sont utiles pour la détection, le diagnostic, le phasage, la supervision, le pronostic, l'imagerie in vivo, la prévention ou le traitement, ou bien la détermination d'une prédisposition aux maladies et aux affections du sein chez un sujet (par exemple, cancer du sein). L'invention concerne en outre des anticorps capables de liaison spécifique avec les polypeptides ou protéines BS135 codés, ainsi que des agonistes ou des inhibiteurs qui entravent l'action du polypeptide BS135 spécifique au tissu. Les molécules considérées sont utiles pour le traitement thérapeutique des maladies, tumeurs ou métastases du sein.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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