C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2293661
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS124 and transcribed from breast tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to a BS124-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS124 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention concerne un ensemble de séquences d'ADN complémentaire contiguës et partiellement chevauchantes, ainsi que les polypeptides codés par ces séquences, ci-après dénommés BS124 et transcrits à partir de tissus mammaires. Lesdites séquences sont utiles pour détecter, diagnostiquer, déterminer les stades, surveiller, pronostiquer, prévenir ou traiter des pathologies mammaires, ou déterminer la prédisposition d'un sujet à ces pathologies et notamment au cancer du sein. L'invention concerne également des anticorps qui se fixent à un polypeptide BS124 codé ou à une protéine BS124 codée, ainsi que les agonistes ou les inhibiteurs prévenant l'action dudit polypeptide BS124 spécifique de certains tissus, les molécules de ce polypeptide étant utiles au traitement thérapeutique des pathologies ou des métastases mammaires ou des tumeurs du sein.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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