C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2399047
Multimeric polypeptides antigens comprising polypeptides designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring prognosticating or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein.
L'invention porte sur un ensemble de séquences d'ARN contiguës et se recouvrant partiellement et sur les polypeptides codés par elles. Lesdites séquences, dites BS106, transcrites à partir de tissus mammaires, peuvent servir à la détection, au diagnostic, à la stadification, au suivi, aux pronostics, à la prévention, et au traitement des maladies et pathologies du sein tels que le cancer, et à déterminer la prédisposition d'un individu à ces maladies et pathologies. L'invention porte également sur des anticorps se fixant spécifiquement aux polypeptide ou protéines codés par les BS106 et sur des agonistes ou inhibiteurs empêchant l'action des polypeptide BS106 spécifiques d'un tissu, ces molécules étant utiles pour le traitement des maladies, tumeurs, et métastases du sein.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Mbm Intellectual Property Law Llp
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