C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2279551
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LU105 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to LU105- encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific LU105 polypeptide, which molecules are useful for the therapeutic treatment of lung diseases, tumors or metastases.
On décrit un ensemble de séquences d'ADNc contiguës, se chevauchant partiellement, et des polypeptides codés par ces dernières, désignés par LU105 et dont la transcription s'effectue à partir de tissu pulmonaire. Ces séquences sont utiles pour détecter, diagnostiquer, évaluer, surveiller, pronostiquer, prévenir ou traiter, ou encore pour déterminer la prédisposition d'un individu à développer des maladies et des affections du poumon tels que le cancer du poumon. On décrit également des anticorps qui se lient de manière spécifique au polypeptide ou à la protéine codé par LU105 et des agonistes ou des inhibiteurs qui empêchent l'action du polypeptide LU105 spécifique au tissu, ces molécules étant utiles pour effectuer le traitement thérapeutique de maladies, de tumeurs et de métastases pulmonaires.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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