A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/42 (2006.01) C07H 21/02 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) G01N 33/53 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2528860
Methods and compositions are provided for the use of rabies virus~neutralizing antibodies for postexposure prophylactic treatment of subjects exposed to rabies virus. Compositions comprising mixtures of rabies virus~neutralizing antibodies, as well as nucleotide and amino acid sequences encoding these antibodies, can be used in the treatment of subjects exposed to rabies virus. The invention also provides methods of producing recombinant rabies virus- neutralizing human antibodies in mammalian cells using recombinant expression vectors.
L'invention concerne des méthodes et des compositions destinées à l'utilisation d'anticorps neutralisant le virus de la rage pour le traitement prophylactique post-exposition de sujets exposés au virus de la rage. Ces compositions contiennent des mélanges d'anticorps neutralisant le virus de la rage, ainsi que des séquences nucléotidiques et des séquences d'acides aminés codant pour ces anticorps, et peuvent être utilisées dans le traitement de sujets exposés au virus de la rage.
Dietzschold Bernhard
Hooper Douglas Craig
Mccarthy Tetrault Llp
Thomas Jefferson University
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