Recombinant myco-bacterial expression vehicles and uses...

Details Recombinant myco-bacterial expression vehicles and uses... Recombinant myco-bacterial expression vehicles and uses...

C - Chemistry, Metallurgy

12

N

167/129, 195/1.1

C12N 15/70 (2006.01) A61K 39/00 (2006.01) C07K 14/35 (2006.01) C12N 1/21 (2006.01) C12N 15/74 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1339526

Recombinant cultivable mycobacteria capable of expressing DNA of interest which encodes at least one protein antigen against which an immune response is mycobacteria. In the recombinant mycobacteria, the DNA of interest is stably maintained extrachromosomally or is stably integrated into genomic DNA. Such recombinant mycobacteria are useful as vehicles to be used as vaccines to provide immunity against a pathogen, as anti-fertility "vaccines" and as a means to nonspecifically augment immune responses to foreign antigens expressed by BCG or to treat human cancers. The present invention also relates to recombinant vectors useful in introducing DNA of interest into mycobacteria, where it is expressed. One type of vector is a recombinant phasmid capable of replicating as a plasmid in E. coli and of lysogenizing a mycobacterial host. A second type of vector is a recombinant plasmid which can be introduced into mycobacteria, where it is stably maintained extrachromosomally. A third type of recombinant vector is one which replicates in E. coli but not in mycobacteria.

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