C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61K 39/385 (2006.01) C07K 1/22 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C07K 17/00 (2006.01) C12N 5/18 (2006.01) C12N 15/86 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2241802
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.
L'invention concerne une protéine recombinante, fabriquée dans un système à baculovirus, dont la séquence polypeptidique constitutive essentielle est celle d'un fragment C-terminal de 19 kilodaltons (p19) de la protéine 1 de surface (protéine MSP-1) de la forme mérozoïte d'un parasite du type Plasmodium, en particulier Plasmodium falciparum, infectieux pour l'Homme, ce fragment C-terminal restant normalement ancré à la surface du parasite au terme de sa phase de pénétration dans des érythrocytes humains, à l'occasion d'un cycle infectieux. Cette protéine recombinante est applicable à la production de vaccins contre la malaria.
Barnwell John W.
Longacre-Andre Shirley
Mendis Kamini
Nato Faridabano
Roth Charles
Institut Pasteur
New York University
Robic
LandOfFree
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