A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61P 37/04 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2510309
The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.
L'invention concerne des compositions pouvant augmenter le pouvoir antigénique d'un vaccin. La composition, ou l'adjuvant, est administrée à un mammifère qui en besoin, consécutivement ou simultanément à un antigène de la vaccine. Dans un aspect préféré, l'adjuvant se présente sous la forme d'un vecteur de proxivirus recombinant, tel qu'un vecteur du virus de la vaccine, qui comprend une séquence d'acide nucléique codant IL-15.
Berzofsky Jay A.
Oh Sang-Kon
Perera Liyange P.
Waldmann Thomas A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
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