C - Chemistry – Metallurgy – 09 – D
Patent
C - Chemistry, Metallurgy
09
D
C09D 4/00 (2006.01) A61L 17/00 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 24/06 (2006.01) A61L 27/00 (2006.01) A61L 29/00 (2006.01) C08F 2/48 (2006.01) C08F 265/04 (2006.01) C08F 271/00 (2006.01) C08F 283/00 (2006.01) C08F 289/00 (2006.01) C08F 290/06 (2006.01) C08F 290/14 (2006.01) C08F 291/00 (2006.01) C09J 151/00 (2006.01) A61B 17/00 (2006.01) A61B 17/08 (2006.01)
Patent
CA 2215309
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
Avila Luis Z.
Barman Shikha P.
Bromander Thomas S.
Coury Arthur J.
Elbert Donald L.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
Focal Inc.
Genzyme Corporation
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