Reduced side-effect hemoglobin compositions

Details Reduced side-effect hemoglobin compositions Reduced side-effect hemoglobin compositions

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2391226

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

La présente invention concerne des compositions d'hémoglobine, en particulier des compositions d'hémoglobine mutante recombinante, qui permettent d'empêcher ou qui réduisent sensiblement 1) la création de liaisons cardiaques, 2) les sensations d'inconfort gastro-intestinal, 3) les effets vasopressifs, et 4) l'hypersensibilité aux endotoxines associée à l'administration de compositions d'hémoglobine extracellulaire dans différentes applications thérapeutiques. Les applications décrites comprennent des traitements contre une anémie, un traumatisme crânien, une hémorragie ou une hypovolémie, une ischémie, une cachexie, un accident ou une crise d'anémie falciforme, pour améliorer des traitements de cancer, stimuler l'hématopoïèse, améliorer une réparation de tissus physiquement endommagés, atténuer un choc cardiogène, et faciliter une réanimation après commotion.

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