Regulation of immunoglobulin production by interleukin-9

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093434

A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin-9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin-4 and interleukin- 9. Production of IgE is inhibited by administering an amount of an interleukin-9 inhibitor to a subject.

On décrit un procédé servant à inhiber la production d'IgE et un procédé servant à augmenter la production d'IgG. Les procédés sont liés au rôle de l'interleukine-9 dans la production d'anticorps. De manière spécifique, la production d'IgG est augmentée lorsqu'on administre soit à un sujet soit à une culture cellulaire une combinaison d'interleukine-4 et d'interleukine-9. La production d'IgE est inhibée lorsqu'on administre une certaine quantité d'un inhibiteur d'interleukine-9 à un sujet.

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