Removal of plasminogen or plasmin from protein solutions

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 9/68 (2006.01) C07K 1/22 (2006.01)

Patent

CA 2447789

A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6 - 8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

L'invention concerne un procédé d'extraction spécifique ou d'isolation de plasmin(ogène) ou de plasmine en présence de fibrinogène d'un mélange contenant du plasmin(ogène) ou du plasmine en mettant en contact le mélange avec un aminoacide rigide dans lequel le groupe amino de l'aminoacide et le groupe carboxylique de l'aminoacide sont d'environ 6 à 8 Angströms, de préférence 7 Angströms environ chacun et l'aminoacide rigide est lié de manière covalente au support par le groupe amino de l'aminoacide.

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