Retentate chromatography and protein chip arrays with...

G - Physics – 01 – N

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Details

G01N 33/566 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/74 (2006.01) H01J 49/04 (2006.01) G01N 30/90 (2006.01) G01N 30/95 (2006.01)

Patent

CA 2294416

This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

L'invention concerne des procédés de chromatographie par rétentat permettant de détecter des analytes dans un échantillon. Ces procédés consistent à adsorber les analytes sur un substrat, dans une pluralité de conditions de sélectivité différentes, et à détecter les analytes retenus sur ce substrat par spectrométrie de désorption. Ces procédés sont utiles en biologie et en médecine, notamment pour des diagnostics cliniques et la découverte de médicaments.

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