C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61P 25/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2367766
Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C which include the amino acid sequence LLEENNDL (all D-amino acids). These peptides induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and neuropathic pain.
La présente invention concerne des analogues peptidiques rétro-inverso dérivés de la région neurotrophique active de la saposine C qui comprend la séquence d'acides aminés LLEENNDL (tous des acides aminés D). Lesdits peptides provoquent la formation de névrite in vitro, inhibent l'apoptose, stimulent la myélinisation et possèdent un effet analgésique. Ils sont également utiles dans le traitement de troubles du système nerveux central et périphérique et de la douleur névropathique.
O'brien John S.
Wright David E.
Barrigar Intellectual Property Law
Myelos Corporation
O'brien John S.
Wright David E.
LandOfFree
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