Rh116 polypeptides and its fragments and polynucleotides...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) A61K 38/14 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/14 (2006.01) C12N 9/90 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408576

The invention concerns a novel 116 kDa polypeptide exhibiting homologies of sequences with RNA helicases (DEXH box) called RH116 and its fragments, the cloning of cDNA and the polynucleotides encoding said polypeptides, cloning and/or expression vectors including said polynucleotides, cells transformed by said vectors and specific antibodies directed against said polypeptides. The invention also concerns methods for detecting and/or assaying said polypeptides and polynucleotides, corresponding diagnosis kits, and a method for screening ligands, as well as compounds for use as medicine for preventing and/or therapeutic treatment.

La présente invention concerne un nouveau polypeptide de 116 kDa présentant des homologies de séquences avec des hélicases à ARN (DEXH box) dénommé RH116 et ses fragments, le clonage de l'ADNc et les polynucléotides codant lesdits polypeptides, des vecteurs de clonage et/ou d'expression incluant lesdits polynucléotides, des cellules transformées par lesdits vecteurs et des anticorps spécifiques dirigés contre lesdits polypeptides. L'invention concerne également des procédés de détection et/ou de dosage desdits polypeptides et polynucléotides, les trousses de diagnostic correspondantes, et un procédé de criblage de ligands, ainsi que des composés utilisables à titre de médicament pour la prévention et/ou le traitement thérapeutique.

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