Ribozyme gene therapy for hiv infection and aids

Details Ribozyme gene therapy for hiv infection and aids Ribozyme gene therapy for hiv infection and aids

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2163129

This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.

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