Ring-closing metathesis process in supercritical fluid

Details Ring-closing metathesis process in supercritical fluid Ring-closing metathesis process in supercritical fluid

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2578428

Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the process is performed in a gaseous fluid at supercritical or near-supercritial conditions. The compounds of formula I are active agents for the treatment of hepatitis C viral (HCV) infections or are intermediates useful for the preparation of anti-HCV agents.

La présente invention a pour objet un procédé de synthèse d~un composé de formule I, qui inclut une étape de cyclisation d~un diène de formule III en présence d~un catalyseur à base de ruthénium, dans un solvant organique approprié. Ladite synthèse est menée dans un fluide gazeux en conditions supercritiques ou quasi-supercritiques. Les composés de formule I sont des principes actifs dans le traitement d~infections dues au virus de l'hépatite C (VHC), ou sont des intermédiaires qui peuvent intervenir dans la synthèse d~agents anti-VHC.

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