Rna interference compositions and methods

Details Rna interference compositions and methods Rna interference compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/46 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2516425

The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

La présente invention concerne des acides nucléiques isolés. L'invention concerne notamment des acides nucléiques isolés présentant au moins un brin porteur de séquences sens et anti-sens qui sont complémentaires les unes des autres. L'invention concerne également des acides nucléiques isolés porteurs d'au moins un brin qui est un gabarit pour les séquences sens et anti-sens qui sont complémentaires l'une par rapport à l'autre. L'invention concerne enfin des cellules, des virus, et des animaux transgéniques, notamment non-humains, contenant un ou plusieurs des acides nucléiques isolés de l'invention ainsi que des procédés d'utilisation de l'un au moins des acides nucléiques isolés de l'invention pour réduire le niveau d'ARN, tel que l'ARN messager, à l'intérieur d'une cellule.

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