C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2755773
The present invention relates to compounds, compo-sitions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of Bach1 gene expression and/or activity, and/or modulate a Bach1 gene ex-pression pathway. Specifically, the invention relates to double--stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short inter-fering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capa-ble of mediating or that mediate RNA interference (RNAi) against Bach1 gene expression.
La présente invention concerne des composés, des compositions, et des procédés pour l'étude, le diagnostic, et le traitement de caractères, maladies et affections qui répondent à la modulation de l'expression génique et/ou activité de Bach1, et/ou modulent une voie d'expression génique de Bach1. Spécifiquement, l'invention concerne des molécules d'acide nucléique bicaténaires comprenant des petites molécules d'acide nucléique, telles que des molécules d'acide nucléique interférant court (ANsi), ARN interférant court (ARNsi), ARN bicaténaire (ARNdb), micro-ARN (miARN), et ARN court en épingle à cheveux (ARNsh) qui sont capables de véhiculer ou qui véhiculent l'ARN interférence (ARNi) contre l'expression génique de Bach 1.
Pickering Victoria
Shah Jyoti
Strapps Walter
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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