Rnai-mediated inhibition of ocular targets

Details Rnai-mediated inhibition of ocular targets Rnai-mediated inhibition of ocular targets

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2595678

RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open- angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; .beta.1- and .beta.2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na-K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.

Selon l'invention, l'interférence ARN permet l'inhibition de l'expression ARNm d'une cible d'hypertension oculaire dans la réduction d'une pression intraoculaire élevée chez des patients présentant un glaucome à angle ouvert ou une hypertension oculaire. Les cibles d'hypertension oculaire comprennent l'anhydrase carbonique II, IV et XII; les récepteurs adrénergiques ß1 et ß2; l'acétylcholinestérase; la Na+/K+-ATPase; et le cotransporteur Na-K-2Cl. L'hypertension oculaire est traitée par administration d'ARN interférents selon l'invention.

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